Addiction in Memory

December 10, 2006 / by MentalHealthRN

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Figure 3. Axons Containing Glutamate and Dopamine Converge onto Dendritic Spines within Striatal and other Corticolimbic Regions(A) An example of a striatal medium-sized spiny neuron from the striatum. A typical cell has extensive dendritic and axonal arborizations, and the dendrites are characterized by numerous protrusions (spines).(B) Close-up schematic view of a dendrite that receives dopaminergic input from the midbrain and glutamatergic input from cortex or thalamic regions synapsing in close apposition on the same dendritic spine. This arrangement has been shown for medium spiny neurons but is thought to exist for neurons in other key regions (such as the pyramidal cells of prefrontal cortex and magnocellualar neurons of basolateral amygdala). (C) Cellular convergence of dopamine (DA) and glutamate (GLU) signals in medium spiny neurons. This convergence leads to activation of intracellular transduction mechanisms, induction of regulatory transcription factors, and, ultimately, long-term changes in cellular plasticity involving a myriad of postsynaptic density proteins, as discussed in the text.

18 comments on Addiction in Memory

  • mommy72900 said 1 years ago
    [HUH] It's been awhile since I took A&P LOL[ROLLEYES][WINK][SMILE]
  • dawgnurse said 1 years ago
    I though A & P was a grocery store. Who knew???[WINK]
  • bluegrasslady said 1 years ago
    ??????
  • experiencinggod said 1 years ago
    [LOL][LOL]I was going to get you to expain it hazel![LOL][LOL][HEART][HEART]
  • MentalHealthRN said 1 years ago
    sorry, I had to get a copy of the above model and could not get it to print. So I decided to download and paste Will erase this post.
  • jondude said 1 years ago
    Love them spiny neurons![THUMBUP] Especially the ones in the frontal cortex.[BLUSH]
  • MentalHealthRN said 1 years ago
    [WINK][BLUSH][WINK]
  • JOEZsREPUBLICANPAGE said 1 years ago
    [WINK] Put tab "A" into slot "T" and tab"M" into slot "B" and where in the heck did the directions go MOTHER the dog ate the #############[THUMBUP][THUMBUP][HEART][WINK]
  • MentalHealthRN said 1 years ago
    [LOL][LOL][LOL][LOL][LOL]
  • docrock said 1 years ago
    This fantastic resource wasn't available 10 yrs ago..
  • dawgnurse said 1 years ago
    I think I snapped a synapse! My neutrons are not speaking to the electrons and the protons are on vacation. I'm just a mess.[WINK][HEART]
  • MentalHealthRN said 1 years ago
    [LOL][LOL][LOL][HEART]
  • janellen said 1 years ago
    [LOL][LOL][LOL]
  • sweethoneydew said 1 years ago
    Just lock me away some place peaceful[ROLLEYES][TONGUE][WINK][BLUSH]
  • Slywoody3 said 1 years ago
    What a coincidence! Yesterday, we were digging foxholes and basolateral amygdala came up in the conversation.[HUH]
  • southwesterngrad said 1 years ago
    All I know is that somewhere between my glutamates and my dopamines, I've blown a few circuits. Not everything comes through the way it once did.[LOL][OHMY][SAD][OHMY]
  • steeve said 1 years ago
    ...and they say lawyers speak gibberish...
  • maggiem said 1 years ago
    I knew that.[COOL]

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